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Influenza virus vaccination of patients with multiple sclerosis

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

Djamshid Shirazian

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

Linda Morgante

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

Aaron Miller

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

David Grob

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

Edgar Lichstein

SUNY Health Science Center/Maimonides Medical Center, 4802 tenth avenue, Brooklyn, 11219 New York, USA

Prior to vaccination with a trivalent influenza vaccine (AT/Texas, AB/Beijing, and BP/Panama), sera from 19 MS patients had a significantly higher mean level of antibody than 9 normal subjects to AT strain of influenza, but not to AB or BP strains. After Flu vaccination, the mean anti-AT and anti-AB antibody titers significantly increased 4-fold in I I MS patients and 9 normal subjects. The ratio of MS responders (6II1), however, was lower than normal (8/9). The mean PBL proliferative response to the Flu antigens increased after vaccination significantly more in MS patients than in normal subjects, and increased in 9 of I I MS patients and 3 of 9 normal subjects. Although MS patients responded to Flu antigens with higher antibody levels and proliferative responses of PBL, than normal subjects, a clinical protective effect of the vaccine against Flu was not dearly demonstrated in these patients, and vaccination did not cause or protect against exacerbation of MS.

Key Words: multiple sclerosis • influenza • placebo • peripheral blood lymphocytes • Kurtzke Extended Disability Status Score

Multiple Sclerosis, Vol. 3, No. 4, 243-247 (1997)
DOI: 10.1177/135245859700300405


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