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Antibodies to the axolemma-enriched fraction in the cerebrospinal fluid and serum of patients with multiple sclerosis and other neurological diseases

Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Richmond, Virginia 23298-0614 USA

VP Calabrese

Department of Neurology, Medical College of Virginia, Richmond, Virginia 23298-0599 USA

OA Khan

Department of Neurology, University of Maryland, Baltimore, Maryland 21201-1595 USA

GH DeVries

Research Service 151, Edward Hines Jr. VA Hospital, 5th and Roosevelt Road, Hines, Illinois 60141 USA

Antibodies to an axolemma-enriched fraction (AEF) antigen have been detected in the cerebrospinal fluid (CSF) and serum of patients with Multiple Sclerosis (MS) using an enzyme-linked immunosorbent assay (ELISA). A marginal elevation (P < 0.08) of anti-AEF lgG was found in MS CSF when compared with OND samples. When CSF was diluted to a standardized lgG concentration, the anti-AEF lgG level in MS CSF was significantly elevated (P=0.007) when compared to OND CSF. MS serum was also found to contain a significantly higher level (P < 0.00 I ) of anti-AEF lgG when compared to OND serum using the ELISA technique.

Key Words: multiple sclerosis • axolemma-enriched fraction • enzyme-linked immunosorbent assay • immunoglobulin G • autoantibody • autoantigen

Multiple Sclerosis, Vol. 3, No. 6, 363-369 (1997)
DOI: 10.1177/135245859700300601


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