This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Jongen, P J. Articles by Lamers, K J. Search for Related Content PubMed PubMed Citation Articles by Jongen, P J. Articles by Lamers, K J. Social Bookmarking                         What's this?

Composite cerebrospinal fluid score in relapsing-remitting and secondary progressive multiple sclerosis

Multiple Sclerosis Centre Nijmegen, Snelliusstraat 6, 6533 NV Nijmegen

S Floris

Multiple Sclerosis Centre Nijmegen, Snelliusstraat 6, 6533 NV Nijmegen

W H Doesburg

Department of Medical Statistics, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen

W AJG Lemmens

Department of Medical Statistics, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen

O R Hommes

Multiple Sclerosis Centre Nijmegen, Snelliusstraat 6, 6533 NV Nijmegen

K JB Lamers

Department of Neurology, University Hospital Nijmegen, P.O. 9101, 6500 HB, Nijmegen, The Netherlands

We investigated whether cerebrospinal fluid (CSF) analysis may differentiate between relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS). In 17 RR and 16 SP patients we determined: albumine CSF/PB ratio; mononuclear cell (MNC) number, CD4+, CD8+, and B1+ subsets, CD4+/CD8+ ratio; IgG, IgG index, IgM, IgM index, complement components C3 and C4, and C3 and C4 indexes; myelin basic protein; neuron-specific enolase (NSE); S100; and lactate. For each parameter the statistical distance was calculated. Then, using linear discriminant analysis, we computed a discriminant score, including only variables with a P value less than or equal to 0.15: albumin CSF/PB ratio, MNC number, IgM, IgM index, C3, C4, NSE, S100, and lactate. The discriminant score allocated all 17 RR patients to the RR group and 15 of 16 SP patients to the SP group. We conclude that RR and SP MS patients differ with respect to CSF profile and that in individual patients a composite CSF score may differentiate between RR and SP MS.

Key Words: multiple sclerosis • cerebrospinal fluid • relapsing-remitting • secondary progressive • diagnosis • discrimination analysis

Multiple Sclerosis, Vol. 4, No. 3, 108-110 (1998)
DOI: 10.1177/135245859800400303


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. Malmestrom, S. Haghighi, L. Rosengren, O. Andersen, and J. Lycke Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS Neurology, December 23, 2003; 61(12): 1720 - 1725. [Abstract] [Full Text] [PDF]

				A. Petzold, M. J. Eikelenboom, D. Gveric, G. Keir, M. Chapman, R. H. C. Lazeron, M. L. Cuzner, C. H. Polman, B. M. J. Uitdehaag, E. J. Thompson, et al. Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations Brain, July 1, 2002; 125(7): 1462 - 1473. [Abstract] [Full Text] [PDF]