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Multiple Sclerosis
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CSF-enriched antibodies do not share specificities among MS patients

I Cortese

Clinica Neurologica, Università di Roma, Tor Vergatce 00100 Roma, and IRCCS S. Lucia, Via Ardeatina 306, 00173 Roma, Italy

S Capone

Istituto di Richerche di Biologia Molecolare P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia (Roma), Italy

S Luchetti

Clinica Neurologica, Università di Roma, Tor Vergatce 00100 Roma, and IRCCS S. Lucia, Via Ardeatina 306, 00173 Roma, Italy

L ME Grimaldi

Neuroimmunology Unit, Department of Neurology, Università degli Studi di Milano, IRCCS Ospedale S. Raffaele, Via Olgettina 58, 20132 Milano, Italy

A Nicosia

Istituto di Richerche di Biologia Molecolare P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia (Roma), Italy

R Cortese

Istituto di Richerche di Biologia Molecolare P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia (Roma), Italy

The specificity of the oligoclonal immunoglobulins found in MS CSF is unknown. We have previously shown that random peptide libraries displayed on phage can be used to identify specific ligands for CSF antibodies. Here we describe the use of this tool in the attempt to identify MS-specific CSF-enriched antibody reactivities with potential pathogenic, diagnostic or prognostic value. Applying different experimental strategies, several ligands reacting with CSF-enriched antibodies were identified. When tested against a panel of 55 MS patients, none of the ligands found were recognized by antibodies shared by any two patients. We used the selected peptides to demonstrate the stability in time of CSF-enriched antibodies notwithstanding disease progression.

Key Words: multiple sclerosis • CSF • oligoclonal bands • phage library

Multiple Sclerosis, Vol. 4, No. 3, 118-123 (1998)
DOI: 10.1177/135245859800400305
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