SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Multiple Sclerosis
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Reder, A. T
Right arrow Articles by Porrini, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reder, A. T
Right arrow Articles by Porrini, A. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Monocyte activation in multiple sclerosis

Anthony T Reder

Department of Neurology, University of Chicago, MC2030 5841 South Maryland Avenue, Chicago, Illinois 60637, USA

Kursad Genc

Department of Neurology, University of Chicago, MC2030 5841 South Maryland Avenue, Chicago, Illinois 60637, USA

Paul V Byskosh

Department of Neurology, University of Chicago, MC2030 5841 South Maryland Avenue, Chicago, Illinois 60637, USA

Anna Maria Porrini

Department of Neurology, University of Chicago, MC2030 5841 South Maryland Avenue, Chicago, Illinois 60637, USA

Monocytes, macrophages, and microglia have a central role in the CNS inflammation of MS. Monocytes are important in the earliest events in MS. Peripheral blood monocytes secrete prostaglandins before MS attacks. During clinical activity monocyte activation markers increase and IL-1 and TNF-a levels are elevated. Other monocyte products such as IL-10 reduce inflammation. IL-10 mRNA in MNC is increased during stable disease. Manipulation of monokine secretion and expression of monocyte surface proteins are reasonable approaches for immune therapy of MS.

Key Words: monocyte • microglia • multiple sclerosis • CD80 • IFN-ß • IFN-{gamma}

Multiple Sclerosis, Vol. 4, No. 3, 162-168 (1998)
DOI: 10.1177/135245859800400314
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
S. Desplat-Jego, L. Feuillet, R. Creidy, I. Malikova, R. Rance, M. Khrestchatisky, K. Hahm, L. C. Burkly, J. Pelletier, and J. Boucraut
TWEAK is expressed at the cell surface of monocytes during multiple sclerosis
J. Leukoc. Biol., January 1, 2009; 85(1): 132 - 135.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Schmidt, H.-G. Pauels, N. Lugering, A. Lugering, W. Domschke, and T. Kucharzik
Glucocorticoids Induce Apoptosis in Human Monocytes: Potential Role of IL-1{beta}
J. Immunol., September 15, 1999; 163(6): 3484 - 3490.
[Abstract] [Full Text] [PDF]


Advertisement