This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rieckmann, P. Articles by Felgenhauer, K Search for Related Content PubMed PubMed Citation Articles by Rieckmann, P. Articles by Felgenhauer, K Social Bookmarking                   What's this?

Correlation of soluble adhesion molecules in blood and cerebrospinal fluid with magnetic resonance imaging activity in patients with multiple sclerosis

Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Würzburg, Germany

Bernd Altenhofen

Department of Neurology, Department of Neuro-radiology, University of Göttingen, Germany

Antje Riegel

Boris Kallmann

Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Würzburg, Germany

K Felgenhauer

Department of Neurology, Department of Neuro-radiology, University of Göttingen, Germany

Several studies have reported a positive correlation between levels of soluble adhesion molecules in serum or cerebrospinal fluid and cranial MRI activity. We performed a cross-sectional study in 46 patients with newly diagnosed MS and determined levels of soluble intercellular adhesion molecule-1 (sICAM-1) as well as vascular cell adhesion molecule-1 (sVCAM-1) in correlation to the number and area of gadolinium enhancing lesions on cranial magnetic resonance images (MRI). The data revealed a significant positive correlation between sVCAM-1 serum levels and gadolinium enhancing lesions. In addition, CSF to serum ratios for sICAM-1 and sVCAM-1 correlated to MRI activity. In patients with a single enhancing lesion (SEL) there was a negative correlation between the QsCAM and the distance of the SEL to the ventricles. As these adhesion molecules are stable and markers of disease activity in MS, we further investigated sVCAM-1 serum levels during treatment with interferon beta-1b (Betaferon®). Significant increases in serum levels for sVCAM-1 in patients receiving Betaferon were associated with a favourable treatment response after 1 year in 17 out of 19 patients and correlated to decreased MRI activity, whereas stable or reduced sVCAM-1 levels occured more often in non-responders (five out of six patients). Therefore it can be hypothezised that soluble adhesion molecules are released from cerebral endothelial cells as an early immunoregulatory activity of the immune system to reduce cellular traffic across the blood brain barrier and this is further enhanced by IFN-beta treatment.

Key Words: adhesion molecules • MRI • multiple sclerosis • Interferon-beta • cerebrospinal fluid • cytokines

Multiple Sclerosis, Vol. 4, No. 3, 178-182 (1998)
DOI: 10.1177/135245859800400317


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Ukkonen, X. Wu, B. Reipert, P. Dastidar, and I. Elovaara Cell surface adhesion molecules and cytokine profiles in primary progressive multiple sclerosis Multiple Sclerosis, July 1, 2007; 13(6): 701 - 707. [Abstract] [PDF]

				C. M. Maier, F. Yu, T. Nishi, S. J. Lathrop, and P. H. Chan Interferon-{beta} Fails to Protect in a Model of Transient Focal Stroke Stroke, April 1, 2006; 37(4): 1116 - 1119. [Abstract] [Full Text] [PDF]

				V Yadav, G Marracci, J Lovera, W Woodward, K Bogardus, W Marquardt, L Shinto, C Morris, and D Bourdette Lipoic acid in multiple sclerosis: a pilot study Multiple Sclerosis, April 1, 2005; 11(2): 159 - 165. [Abstract] [PDF]

				A. I. Boullerne, J. J. Rodriguez, T. Touil, B. Brochet, S. Schmidt, N. D. Abrous, M. Le Moal, J. R. Pua, M. A. Jensen, W. Mayo, et al. Anti-S-Nitrosocysteine Antibodies Are a Predictive Marker for Demyelination in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis J. Neurosci., January 1, 2002; 22(1): 123 - 132. [Abstract] [Full Text] [PDF]

				A. Minagar, W. Jy, J. J. Jimenez, W. A. Sheremata, L. M. Mauro, W. W. Mao, L. L. Horstman, and Y. S. Ahn Elevated plasma endothelial microparticles in multiple sclerosis Neurology, May 22, 2001; 56(10): 1319 - 1324. [Abstract] [Full Text] [PDF]

				B. A. Kallmann, V. Hummel, T. Lindenlaub, K. Ruprecht, K. V. Toyka, and P. Rieckmann Cytokine-induced modulation of cellular adhesion to human cerebral endothelial cells is mediated by soluble vascular cell adhesion molecule-1 Brain, April 1, 2000; 123(4): 687 - 697. [Abstract] [Full Text] [PDF]