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Free light chains in multiple sclerosis urine

Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314-6399, USA

S D Cook

Department of Neurology, UMDNJ-New Jersey School of Medicine, Newark, NJ 07103, USA

P K Coyle

Department of Neurology, Health Sciences Center, SUNY at Stony Brook, Stony Brook, NY 11794, USA

R A Troiano

Department of Neurology, UMDNJ-New Jersey School of Medicine, Newark, NJ 07103, USA

C S Constantinescu

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA

A M Rostami

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA

We measured free kappa (k) and lambda (l) light chains in urine from patients with definite multiple sclerosis (MS), other neurologic diseases (OND), and normal controls by using an enzyme linked immunosorbent assay. Both k and l light chains were higher in MS than OND or controls. In seven of eight relapsing-remitting (R-R) MS patients serial studies showed that urinary k chains were elevated during periods of worsening, and decreased during clinical recovery. In contrast, the levels of k chains did not correlate with clinical activity in 10 progressive (P) MS patients. Further correlation of urinary light chains with neurologic evaluations in R-R and P MS patients over a longer period are needed to determine their clinical and biological relevance.

Key Words: Multiple sclerosis • free light chains • urine • creatinine • enzyme linked immunosorbent assay

Multiple Sclerosis, Vol. 4, No. 3, 254-256 (1998)
DOI: 10.1177/135245859800400331


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