This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reiber, H. Search for Related Content PubMed PubMed Citation Articles by Reiber, H. Social Bookmarking                         What's this?

Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases

Neurochemisches Labor der Neurologischen Klinik, Universitat Göttingen, Germany

The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding: (1) The physiology and pathophysiology of blood-CSF barrier function and dysfunction with the CSF flow rate as main modulator of blood- and brain-derived protein concentrations in CSF; (2) The neuroimmunological aspects regarding (a) patterns of disease-related immunoglobulin class response (IgG, lgA, IgM) in actual Reiber graphs with reference to specific parameters and optional tests, and (b) the oligoclonal, polyspecific antibody synthesis in brain; (3) Particular marker proteins in CSF and blood for differential diagnosis of neurological diseases; (4) Mathematical base for evaluations of CSF data with an example of a multiple sclerosis patient for calculation of intrathecal immunoglobulin and antibody synthesis as well as Antibody Index.

Key Words: cerebrospinal fluid • protein patterns • analysis • physiology • pathophysiology • blood-CSF barrier function • neuro immunology

Multiple Sclerosis, Vol. 4, No. 3, 99-107 (1998)
DOI: 10.1177/135245859800400302


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S Jarius, D Franciotta, R Bergamaschi, S Rauer, K P Wandinger, H F Petereit, M Maurer, H Tumani, A Vincent, P Eichhorn, et al. Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1134 - 1136. [Abstract] [Full Text] [PDF]

				K. A. Strauss, J. Lazovic, M. Wintermark, and D. H. Morton Multimodal imaging of striatal degeneration in Amish patients with glutaryl-CoA dehydrogenase deficiency Brain, July 1, 2007; 130(7): 1905 - 1920. [Abstract] [Full Text] [PDF]

				S. Cepok, B. Rosche, V. Grummel, F. Vogel, D. Zhou, J. Sayn, N. Sommer, H.-P. Hartung, and B. Hemmer Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis Brain, July 1, 2005; 128(7): 1667 - 1676. [Abstract] [Full Text] [PDF]

				V. Leoni, T. Masterman, P. Patel, S. Meaney, U. Diczfalusy, and I. Bjorkhem Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers J. Lipid Res., April 1, 2003; 44(4): 793 - 799. [Abstract] [Full Text] [PDF]

				N. Marchi, V. Fazio, L. Cucullo, K. Kight, T. Masaryk, G. Barnett, M. Volgelbaum, M. Kinter, P. Rasmussen, M. R. Mayberg, et al. Serum Transthyretin Monomer as a Possible Marker of Blood-to-CSF Barrier Disruption J. Neurosci., March 1, 2003; 23(5): 1949 - 1955. [Abstract] [Full Text] [PDF]

				M. M. Verbeek, H. P.M. de Reus, and C. W. Weykamp Comparison of Methods for the Detection of Oligoclonal IgG Bands in Cerebrospinal Fluid and Serum: Results of the Dutch Quality Control Survey Clin. Chem., September 1, 2002; 48(9): 1578 - 1580. [Full Text] [PDF]

				S. Richard, V. Miossec, J.-F. Moreau, and J.-L. Taupin Detection of Oligoclonal Immunoglobulins in Cerebrospinal Fluid by an Immunofixation-Peroxidase Method Clin. Chem., January 1, 2002; 48(1): 167 - 173. [Abstract] [Full Text] [PDF]