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Multiple Sclerosis
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Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis

Hamed Zouali

Centre d'Etude du Polymorphisme Humain, Paris

Laurence Faure-Delanef

Centre d'Etude du Polymorphisme Humain, Paris

Gérard Lucotte

Centre d'Etude du Polymorphisme Humain, Paris

We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (w2=7.82), showing a significant effect (P50.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P50.03) of allele 1. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.

Key Words: multiple sclerosis (MS) • apolipoprotein C-II gene • microsatellite allelic frequencies • genetic susceptibility • chromosome 19q13.2 region

Multiple Sclerosis, Vol. 5, No. 2, 134-136 (1999)
DOI: 10.1177/135245859900500211
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