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Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials

Robarts Research Institute, 100 Perth Drive, London Health Sciences Center, University Campus, London, Ontario, Canada N6A 5K8

J S Gati

Laboratory for Functional Magnetic Resonance Research, London Health Sciences Center, University Campus, London, Ontario, Canada

R S Menon

Robarts Research Institute, 100 Perth Drive, London Health Sciences Center, University Campus, London, Ontario, Canada N6A 5K8, Laboratory for Functional Magnetic Resonance Research, London Health Sciences Center, University Campus, London, Ontario, Canada

D Lee

Department of Diagnostic Radiology and Nuclear Medicine, London Health Sciences Center, University Campus, London, Ontario, Canada

G Rice

Department of Neurology, London Health Sciences Center, University Campus, London, Ontario, Canada

J R Mitchell

Department of Diagnostic Radiology and Nuclear Medicine, London Health Sciences Center, University Campus, London, Ontario, Canada

P Mandelfino

Department of Neurology, London Health Sciences Center, University Campus, London, Ontario, Canada

S J Karlik

Department of Diagnostic Radiology and Nuclear Medicine, London Health Sciences Center, University Campus, London, Ontario, Canada

The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRI and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topographic information relating to functional deficits in MS.

Key Words: functional magnetic resonance imaging • multiple sclerosis • optic neuritis • visual stimulation • visual evoked potentials • neurophysiological tests

Multiple Sclerosis, Vol. 5, No. 3, 161-164 (1999)
DOI: 10.1177/135245859900500304


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