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Multiple Sclerosis
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Treatment adherence and patient retention in the first year of a Phase-III clinical trial for the treatment of multiple sclerosis

David C Mohr

UCSF/Mt.Zion MS Center, 1701 Divisadero St., San Francisco, CA, 94115-1642, USA

Donald E Goodkin

UCSF/Mt.Zion MS Center, 1701 Divisadero St., San Francisco, CA, 94115-1642, USA

Lorianne Masuoka

Berlex Laboratories, 15049 San Pablo Ave., Richmond, California, CA 94804, USA

Leah P Dick

UCSF/Mt.Zion MS Center, 1701 Divisadero St., San Francisco, CA, 94115-1642, USA

David Russo

UCSF/Mt.Zion MS Center, 1701 Divisadero St., San Francisco, CA, 94115-1642, USA

Jannelle Eckhardt

UCSF/Mt.Zion MS Center, 1701 Divisadero St., San Francisco, CA, 94115-1642, USA

Arne C Boudewyn

Berlex Laboratories, 15049 San Pablo Ave., Richmond, California, CA 94804, USA

Lisa Bedell

Berlex Laboratories, 15049 San Pablo Ave., Richmond, California, CA 94804, USA

The purpose of this study was to examine the relationship between patient management strategies employed by study personnel, and patient retention and adherence to treatment in the first year of a Phase III clinical trial of interferon beta-1b for treatment of secondary progressive multiple sclerosis (MS). Study staff from each of 35 sites were interviewed regarding patient management practices. Sites which were rated as more empathetic, as instilling a sense of purpose in the patient, and promoting less formal relationships with patients had high rates of adherence to treatment. In addressing specific patient concerns, attention to patients' emotional status and patients' expectations of trial participation were related to better adherence.

Key Words: multiple sclerosis • clinical trials • adherence • compliance

Multiple Sclerosis, Vol. 5, No. 3, 192-197 (1999)
DOI: 10.1177/135245859900500309
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This article has been cited by other articles:


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A.P. Turner, D.R. Kivlahan, A.P. Sloan, and J.K. Haselkorn
Predicting ongoing adherence to disease modifying therapies in multiple sclerosis: utility of the health beliefs model
Multiple Sclerosis, November 1, 2007; 13(9): 1146 - 1152.
[Abstract] [PDF]

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J. Rio, J. Porcel, N. Tellez, A. Sanchez-Betancourt, M a. Tintore, M J. Arevalo, C. Nos, and X. Montalban
Factors related with treatment adherence to interferon b and glatiramer acetate therapy in multiple sclerosis
Multiple Sclerosis, June 1, 2005; 11(3): 306 - 309.
[Abstract] [PDF]


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