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Multiple sclerosis and tonsillectomy: no evidence for an influence on the development of disease or clinical phenotype

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

J Deans

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

S JS Chataway

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

S J Sawcer

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

D AS Compston

University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK, Cambridge Centre for Brain Repair, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK

The notion that cervical lymphatic surgery may influence the development of multiple sclerosis has been suggested before. Recent work in experimental allergic encephalomyelitis lends further support to this idea. We, therefore conducted a case: control study of tonsillectomy in multiple sclerosis. We found no evidence to suggest that tonsillectomy affect susceptibility to multiple sclerosis. This result support previous studies, which have largely failed to show any link between prior tonsillectomy and the subsequent development of multiple sclerosis. In addition, we failed to show any effect of tonsillectomy on the extent of cerebral demyelination as assessed clinically or with magnetic resonance imaging.

Key Words: multiple-sclerosis • tonsillectomy • EAE • case-control • epidemiology • susceptibility

Multiple Sclerosis, Vol. 6, No. 2, 121-123 (2000)
DOI: 10.1177/135245850000600211


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