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Multiple Sclerosis
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Leukotropic herpesviruses in multiple sclerosis

Kathleen A Hay

Department of Medicine (Neurology), Penn State University College of Medicine, Hershey, Pennsylvania, USA

Richard B Tenser

Department of Medicine (Neurology), Penn State University College of Medicine, Hershey, Pennsylvania, USA, Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, Pennsylvania, USA

Detection frequency of human herpesvirus 6 (HHV-6) and Epstein Barr virus (EBV) DNA in multiple sclerosis (MS) patient and controls was investigated. DNA of peripheral blood mononuclear leukocytes (PBL) was isolated and amplified by polymerase chain reaction techniques. EBV DNA was detected in all patients and controls. HHV-6 DNA was detected in 7% of MS patient and in 14% of controls. Result are compared with other investigations of HHV-6 DNA in PBL, serum, CSF and brain of patient with MS. Result of the present study and other investigations do not show an association between HHV-6 in PBL and MS.

Key Words: human herpesvirus 6 • multiple sclerosis

Multiple Sclerosis, Vol. 6, No. 2, 66-68 (2000)
DOI: 10.1177/135245850000600202
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