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TNF- polymorphisms in multiple sclerosis: no association with –238 and –308 promoter alleles, but the microsatellite allele all is associated with the disease in French patients

Center of Molecular Neurogenetics, Faculty of Medicine, Rheims, France

Christian Bathelier

Center of Molecular Neurogenetics, Faculty of Medicine, Rheims, France

Géraldine Mercier

Center of Molecular Neurogenetics, Faculty of Medicine, Rheims, France

Tumor necrosis faaor- (TNF-), a proinflammatory cytokine, is believed to play an important role in multiple sclerosis (MS) pathogenesis. The objective of this study was to determine whether sequence variation in the TNF- gene is associated with MS. Bi-allelic polymorphisms in the TNF- promoter region (TNF- –238 and –308) and microsatellite TNF- were previously reported. We investigated these polymorphisms in 74 French patients with MS, compared with 75 controls. No significant differences regarding the TNF- –238 and –308 polymorphisms were observed between MS patient and controls Allele frequency for the all allele is in very significant association (P < 0.0001) with MS, due in part to the assoiation of the all allele with the HLA-DRBI*15 allele in patients.

Key Words: multiple sclerosis (MS) • tumor necrosis factor- (TNF-) • TNF- promoter polymorphisms –238 and –308 • microsatellite TNF-< • HLA-DRBI*15 allele

Multiple Sclerosis, Vol. 6, No. 2, 78-80 (2000)
DOI: 10.1177/135245850000600204


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