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Antinuclear antibodies and response to IFNß-1a therapy in relapsing-remitting multiple sclerosis

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

F Bagnato

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

C Mainero

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

M Salvetti

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

A Paolillo

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

C Gasperini

S. Camillo Hospital, Rome, Italy

S Bastianello

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

C Pozzilli

Department of Neurological Sciences, University of Rome `La Sapienza', Rome, Italy

We determined whether positive ANA was related to response to rIFNû-1a in 62 relapsing-remitting MS patients. According to the presence of antinuclear antibodies (ANA) at baseline and during the first 6 months of treatment, patients were sorted in different groups. The clinical and MRI outcome during short-term (6 months) and long-term (24 months) treatment period was not statistically different between the groups. Therefore, the response to IFNb-1a seems not to be influenced by ANA occurrence either before or during treatment. When the analysis was extended to other autoantibodies (i.e. antithyroid, anticardiolipin) similar results were obtained.

Key Words: multiple sclerosis • antinuclear antibodies • autoantibodies • interferon beta-1a • therapeutical response • disease activity

Multiple Sclerosis, Vol. 6, No. 3, 137-139 (2000)
DOI: 10.1177/135245850000600301


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