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Multiple Sclerosis
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pattern of cytokine secretion by peripheral blood cells of patients with multiple sclerosis in Brazil

Patrícia Mara da Costa

Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil

Clarissa Lin Yasuda

Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil

Silvia M Scagliusi

Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil

Blanca Maria Diaz-Bardales

Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil

Ernane Maciel

Department of Neurology, Medical School, UNICAMP, Campinas, Brazil

Benito P Damasceno

Department of Neurology, Medical School, UNICAMP, Campinas, Brazil

M Heloisa SL Blotta

Department Clinical Pathology, University of Campinas, UNICAMP, Campinas, Brazil

Charles P Tilbery

Department of Neurology, Medical School, Santa Casa de São Paulo, SP-Brazil

Leonilda MB Santos

Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil

Autoimmune T cells play a key role as regulators and effectors of organ-specific autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components produce a plethora of inflammatory cytokines and mediators that contribute to myelin damage. The production of proinflammatory and regulatory cytokines by peripheral blood cells from patients with active and stable MS and healthy controls were examined. The results show that TNFa production was somewhat elevated in active MS with no significant increase in the level IFNg, whereas in the chronic phase the anti-inflammatory cytokines IL-10 and TGFb increased, accompanied by a reduction in IFNg when stimulated by myelin basic protein.

Key Words: cytokines • myelin basic protein • autoimmunity

Multiple Sclerosis, Vol. 6, No. 5, 293-299 (2000)
DOI: 10.1177/135245850000600501
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