This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Luks, T L Articles by Sloan, R Search for Related Content PubMed PubMed Citation Articles by Luks, T L Articles by Sloan, R Social Bookmarking                   What's this?

A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis

Department of Radiology, University of California at San Francisco, AC-109, 1 Irving St, San Francisco, California, CA 94143, USA

D E Goodkin

UCSF/Mt. Zion Multiple Sclerosis Center, 1710 Divisadero Street, San Francisco, California, CA 94115, USA

S J Nelson

Department of Radiology, University of California at San Francisco, AC-109, 1 Irving St, San Francisco, California, CA 94143, USA

S Majumdar

Department of Radiology, University of California at San Francisco, AC-109, 1 Irving St, San Francisco, California, CA 94143, USA

P Bacchetti

Department of Biostatistics and Epidemiology, University of California at San Francisco, 500 Parnasus Ave. 420 MU-W, California, CA 94143, USA

D Portnoy

Department of Radiology, University of California at San Francisco, AC-109, 1 Irving St, San Francisco, California, CA 94143, USA

R Sloan

Department of Radiology, University of California at San Francisco, AC-109, 1 Irving St, San Francisco, California, CA 94143, USA

The specific aim of this study was to determine whether progressive brain atrophy could be detected within 18 months of establishing a diagnosis of relapsing-remitting multiple sclerosis (RRMS). Fifteen patients with clinically definite RRMS (mean disease duration from first symptom=6 months, mean EDSS=1.2) completed 6-14 monthly quantitative MRI sessions. The volume of the lateral ventricles was determined each month using a semi-automated thresholding technique from T1-weighted axial images. The number of new monthly gadolinium-enhancing (Gd+) lesions and EDSS scores were also recorded. Lateral ventricular volumes increased significantly during this study. When individual data were examined, statistically significant changes were observed in six of 15 patients. Monthly change in ventricular volume was related to baseline EDSS and total number of new Gd+ lesions. These observations indicate brain atrophy, a putative imaging marker of diffuse demyelination and axonal loss, can occur as early as 18 months after first symptons of RRMS, and is related to the baseline level of disability and to the number of new Gd+ lesions.

Key Words: multiple sclerosis • atrophy • MRI • ventricular volume

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J H Simon Brain atrophy in multiple sclerosis: what we know and would like to know Multiple Sclerosis, November 1, 2006; 12(6): 679 - 687. [Abstract] [PDF]

				N. D. Richert, T. Howard, J. A. Frank, R. Stone, J. Ostuni, J. Ohayon, C. Bash, and H. F. McFarland Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis Neurology, February 28, 2006; 66(4): 551 - 556. [Abstract] [Full Text] [PDF]

				J Versijpt, J C Debruyne, K J Van Laere, F De Vos, J Keppens, K Strijckmans, E Achten, G Slegers, R A Dierckx, J Korf, et al. Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study Multiple Sclerosis, April 1, 2005; 11(2): 127 - 134. [Abstract] [PDF]

				E. Pagani, M. A. Rocca, A. Gallo, M. Rovaris, V. Martinelli, G. Comi, and M. Filippi Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 341 - 346. [Abstract] [Full Text] [PDF]

				D T Chard, C M Griffin, W Rashid, G R Davies, D R Altmann, R Kapoor, G J Barker, A J Thompson, and D H Miller Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis Multiple Sclerosis, August 1, 2004; 10(4): 387 - 391. [Abstract] [PDF]

				M. Hardmeier, S. Wagenpfeil, P. Freitag, E. Fisher, R. A. Rudick, M. Kooijmans-Coutinho, M. Clanet, E. W. Radue, and L. Kappos Atrophy Is Detectable Within a 3-Month Period in Untreated Patients With Active Relapsing Remitting Multiple Sclerosis Arch Neurol, December 1, 2003; 60(12): 1736 - 1739. [Abstract] [Full Text] [PDF]

				R. Rudick Mechanisms of disability progression in primary progressive multiple sclerosis: are they different from secondary progressive multiple sclerosis? Multiple Sclerosis, April 1, 2003; 9(2): 210 - 212. [PDF]

				B. Turner, X. Lin, G. Calmon, N. Roberts, and L. D Blumhardt C erebral atrophy and disability in relapsing-remitting and secondary progressive multiple sclerosis over four years Multiple Sclerosis, February 1, 2003; 9(1): 21 - 27. [Abstract] [PDF]

				E L. Hoogervorst, C H Polman, and F Barkhof Cerebral volume changes in multiple sclerosis patients treated with high-dose intravenous methylprednisolone Multiple Sclerosis, October 1, 2002; 8(5): 415 - 419. [Abstract] [PDF]

				R Leigh, J Ostuni, D Pham, A Goldszal, B K Lewis, T Howard, N Richert, H McFarland, and J A Frank Estimating cerebral atrophy in multiple sclerosis patients from various MR pulse sequences Multiple Sclerosis, October 1, 2002; 8(5): 420 - 429. [Abstract] [PDF]

				N. De Stefano, S. Narayanan, S. J. Francis, S. Smith, M. Mortilla, M. C. Tartaglia, M. L. Bartolozzi, L. Guidi, A. Federico, and D. L. Arnold Diffuse Axonal and Tissue Injury in Patients With Multiple Sclerosis With Low Cerebral Lesion Load and No Disability Arch Neurol, October 1, 2002; 59(10): 1565 - 1571. [Abstract] [Full Text] [PDF]

				D. T. Chard, C. M. Griffin, G. J. M. Parker, R. Kapoor, A. J. Thompson, and D. H. Miller Brain atrophy in clinically early relapsing-remitting multiple sclerosis Brain, February 1, 2002; 125(2): 327 - 337. [Abstract] [Full Text] [PDF]