Multiple Sclerosis

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Di Marco, R.
Right arrow Articles by Nicoletti, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Di Marco, R.
Right arrow Articles by Nicoletti, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Multiple Sclerosis, Vol. 7, No. 2, 101-104 (2001)
DOI: 10.1177/135245850100700205

Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

Roberto Di Marco

Department of Microbiological and Gynaecological Sciences, University of Catania, Catania, Italy

Gaetano Puglisi

Department of Microbiological and Gynaecological Sciences, University of Catania, Catania, Italy

Gianpaolo Papaccio

Institute of Histology and Embryology, School of Medicine, Second University of Naples, Naples, Italy

Alessandra Nicoletti

Institute of Neurology, University of Catania, Catania, Italy

Francesco Patti

Institute of Neurology, University of Catania, Catania, Italy

Arturo Reggio

Institute of Neurology, University of Catania, Catania, Italy

Klaus Bendtzen

Institute for Inflammation Research, Rigshospitalet University Hospital, Copenhagen, Denmark

Ferdinando Nicoletti

Department of Clinical Medicine, Prevention and Biotechnological Health, University of Milan, Bicocca, Italy

We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

Key Words: experimental allergic encephalomyelitis • immunotherapy • multiple sclerosis • sodium fusidate


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?