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Multiple Sclerosis
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Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis

H B Rasmussen

Department of Life Sciences and Chemistry, Roskilde University, 1 Universitetsvej, DK-4000 Roskilde, Denmark

M A Kelly

Department of Medicine, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

J Clausen

Department of Life Sciences and Chemistry, Roskilde University, 1 Universitetsvej, DK-4000 Roskilde, Denmark

Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the DRB1*1501, DQA1*0102, DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. Possible implications of our finding to future studies of the genetic background of MS is discussed.

Key Words: Multiple sclerosis • genetic susceptibility • human leukocyte antigens • DR15 genotype • meta-analysis

Multiple Sclerosis, Vol. 7, No. 2, 91-93 (2001)
DOI: 10.1177/135245850100700203
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