This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Durán, I Articles by Montalban, X Search for Related Content PubMed PubMed Citation Articles by Durán, I Articles by Montalban, X Social Bookmarking                         What's this?

Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis

Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital Vall d'Hebron. E-08035 Barcelona, Spain

E M Martínez-Cáceres

Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital Vall d'Hebron. E-08035 Barcelona, Spain

L Brieva

Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital Vall d'Hebron. E-08035 Barcelona, Spain

M Tintoré

Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital Vall d'Hebron. E-08035 Barcelona, Spain

X Montalban

Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital Vall d'Hebron. E-08035 Barcelona, Spain

Cytokines play an important role in the initiation and maintenance of the inflammatory reaction in multiple sclerosis, a chronic inflammatory demyelinating disease of the central nervous system. Magnetic resonance imaging evidence supports clinical divergence between forms of multiple sclerosis with relapses and the primary progressive form without relapses, which shows fewer and smaller inflammatory lesions. With the aim of understanding better the relative role of pro-inflammatory and/or anti-inflammatory cytokines in primary progressive multiple sclerosis in comparison to relapsing forms, we analysed in 65 patients (24 primary progressive, 20 relapsing-remitting and 21 secondary progressive) and 29 healthy controls, the production of cytokines (IFN-g, TNF-a, IL-6, IL-10 and IL-12) by peripheral blood mononuclear cells after in vitro stimulation. We found a similar percentage of cytokines producing cells between healthy controls and the different clinical forms of multiple sclerosis patients. Multiple Sclerosis (2001) 7, 151-156

Key Words: multiple sclerosis • primary progressive • cytokines • pathogenesis

Multiple Sclerosis, Vol. 7, No. 3, 151-156 (2001)
DOI: 10.1177/135245850100700303


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				X Montalban and A J Thompson Workshop on primary progressive multiple sclerosis: meeting summary Multiple Sclerosis, April 1, 2002; 8(2): 177 - 178. [PDF]

				O. Neuhaus and H.-P. Hartung In search of a disease marker: the cytokine profile of primary progressive multiple sclerosis Multiple Sclerosis, June 1, 2001; 7(3): 143 - 144. [PDF]