This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Spitsin, S Articles by Koprowski, H Search for Related Content PubMed PubMed Citation Articles by Spitsin, S Articles by Koprowski, H Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Multiple Sclerosis Social Bookmarking                         What's this?

Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins

Department of Immunology & Microbiology, Thomas Jefferson University, 1020 Locust Street, JAH Room M-81, Philadelphia, Pennsylvania, PA 19107, USA

D C Hooper

Department of Immunology & Microbiology, Thomas Jefferson University, 1020 Locust Street, JAH Room M-81, Philadelphia, Pennsylvania, PA 19107, USA

T Mikheeva

Department of Immunology & Microbiology, Thomas Jefferson University, 1020 Locust Street, JAH Room M-81, Philadelphia, Pennsylvania, PA 19107, USA

H Koprowski

Department of Immunology & Microbiology, Thomas Jefferson University, 1020 Locust Street, JAH Room M-81, Philadelphia, Pennsylvania, PA 19107, USA

Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.

Key Words: autoimmunity • twins • demyelinating diseases • multiple sclerosis • uric acid • inosine

Multiple Sclerosis, Vol. 7, No. 3, 165-166 (2001)
DOI: 10.1177/135245850100700305


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. K. Kutzing and B. L. Firestein Altered Uric Acid Levels and Disease States J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 1 - 7. [Abstract] [Full Text] [PDF]

				M. Weisskopf, E O'Reilly, H Chen, M. Schwarzschild, and A Ascherio Plasma Urate and Risk of Parkinson's Disease Am. J. Epidemiol., September 1, 2007; 166(5): 561 - 567. [Abstract] [Full Text] [PDF]

				P. Pacher, J. S. Beckman, and L. Liaudet Nitric Oxide and Peroxynitrite in Health and Disease Physiol Rev, January 1, 2007; 87(1): 315 - 424. [Abstract] [Full Text] [PDF]

				G. S. Scott, S. Cuzzocrea, T. Genovese, H. Koprowski, and D. C. Hooper Uric acid protects against secondary damage after spinal cord injury PNAS, March 1, 2005; 102(9): 3483 - 3488. [Abstract] [Full Text] [PDF]

				G. S. Scott, S. V. Spitsin, R. B. Kean, T. Mikheeva, H. Koprowski, and D. C. Hooper Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors PNAS, December 10, 2002; 99(25): 16303 - 16308. [Abstract] [Full Text] [PDF]

				S Spitsin, D C Hooper, T Leist, L J Streletz, T Mikheeva, and H Koprowski Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease Multiple Sclerosis, October 1, 2001; 7(5): 313 - 319. [Abstract] [PDF]