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Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination-possible markers for an antibody-mediated process

Department of Neuropathology, Charité, Humboldt-Universität, Berlin, Germany

Katrin Neubert

Department of Neurology, Charité, Humboldt-Universität, Berlin, Germany

Thomas Berger

Department of Neurology, University of Innsbruck, Austria

Joerg R Weber

Department of Neurology, Charité, Humboldt-Universität, Berlin, Germany

The present report describes immunopathological, radiologcal and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (1) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in T1-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.

Key Words: Multiple sclerosis • antibody • plasmapheresis

Multiple Sclerosis, Vol. 7, No. 3, 173-177 (2001)
DOI: 10.1177/135245850100700307


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