This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sharma, R. Articles by Wolinsky, J. S Search for Related Content PubMed PubMed Citation Articles by Sharma, R. Articles by Wolinsky, J. S Social Bookmarking                         What's this?

Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging

Department of Radiology, University of Texas at Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA

Ponnada A Narayana

Department of Radiology, University of Texas at Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA

Jerry S Wolinsky

Department of Neurology, University of Texas at Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA

Pathologically defined abnormalities in the cortical gray matter (GM) are well described in multiple sclerosis (MS) but are infrequently seen by conventional magnetic resonance imaging (MRI). We systematically evaluated 52 relapsing - remitting MS patients and 20 normal volunteers with high resolution MRI and short echo proton magnetic resonance spectroscopic imaging (MRSI). Individual tissue contributions to the spectroscopic voxels were estimated based on MRI that incorporated both CSF suppression and magnetization transfer, or double inversion images in which both CSF and GM were suppressed. Strong resonances in the 0.8 to 1.5 p.p.m. spectral region were observed in 13 MS patients. Image segmentation based on the MRI characteristics of tissues contributing to the spectroscopic voxels showed that these additional peaks originated mainly from GM. The presence of these additional peaks suggests that the normal appearance GM on MRI, is biochemically abnormal in a substantial proportion of relapsing-remitting MS patients.

Key Words: MRI • MRSI • multiple sclerosis • lipids • tissue segmentation

Multiple Sclerosis, Vol. 7, No. 4, 221-226 (2001)
DOI: 10.1177/135245850100700402


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. Das Sarma, L. C. Kenyon, S. T. Hingley, and K. S. Shindler Mechanisms of Primary Axonal Damage in a Viral Model of Multiple Sclerosis J. Neurosci., August 19, 2009; 29(33): 10272 - 10280. [Abstract] [Full Text] [PDF]

				L. Roccatagliata, L. Vuolo, L. Bonzano, A. Pichiecchio, and G. L. Mancardi Multiple Sclerosis: Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with the Secondary Progressive Subtype Radiology, May 1, 2009; 251(2): 503 - 510. [Abstract] [Full Text] [PDF]

				N. De Stefano, M. Filippi, D. Miller, P. J. Pouwels, A. Rovira, A. Gass, C. Enzinger, P. M. Matthews, and D. L. Arnold Guidelines for using proton MR spectroscopy in multicenter clinical MS studies Neurology, November 13, 2007; 69(20): 1942 - 1952. [Abstract] [Full Text] [PDF]

				I. Tsunoda, T. Tanaka, Y. Saijoh, and R. S. Fujinami Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration Am. J. Pathol., November 1, 2007; 171(5): 1563 - 1575. [Abstract] [Full Text] [PDF]

				F. Nelson, A.H. Poonawalla, P. Hou, F. Huang, J.S. Wolinsky, and P.A. Narayana Improved Identification of Intracortical Lesions in Multiple Sclerosis with Phase-Sensitive Inversion Recovery in Combination with Fast Double Inversion Recovery MR Imaging AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1645 - 1649. [Abstract] [Full Text] [PDF]

				R. P. Lisak Neurodegeneration in multiple sclerosis: Defining the problem Neurology, May 29, 2007; 68(22_suppl_3): S5 - S12. [Abstract] [Full Text] [PDF]

				I. Pirko, C. F. Lucchinetti, S. Sriram, and R. Bakshi Gray matter involvement in multiple sclerosis Neurology, February 27, 2007; 68(9): 634 - 642. [Abstract] [Full Text] [PDF]

				A. Kangarlu, E.C. Bourekas, A. Ray-Chaudhury, and K.W. Rammohan Cerebral Cortical Lesions in Multiple Sclerosis Detected by MR Imaging at 8 Tesla AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 262 - 266. [Abstract] [Full Text] [PDF]

				B. Audoin, K. T. M. Fernando, J. K. Swanton, A. J. Thompson, G. T. Plant, and D. H. Miller Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis Brain, April 1, 2006; 129(4): 1031 - 1039. [Abstract] [Full Text] [PDF]

				Z. Caramanos, S. Narayanan, and D. L. Arnold 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review Brain, November 1, 2005; 128(11): 2483 - 2506. [Abstract] [Full Text] [PDF]

				R. A. Bermel, S. R. Puli, R. A. Rudick, B. Weinstock-Guttman, E. Fisher, F. E. Munschauer III, and R. Bakshi Prediction of Longitudinal Brain Atrophy in Multiple Sclerosis by Gray Matter Magnetic Resonance Imaging T2 Hypointensity Arch Neurol, September 1, 2005; 62(9): 1371 - 1376. [Abstract] [Full Text] [PDF]

				W. Staffen, H. Zauner, A. Mair, A. Kutzelnigg, P. Kapeller, H. Stangl, E. Raffer, H. Niederhofer, and G. Ladurner Magnetic Resonance Spectroscopy of Memory and Frontal Brain Region in Early Multiple Sclerosis J Neuropsychiatry Clin Neurosci, August 1, 2005; 17(3): 357 - 363. [Abstract] [Full Text] [PDF]

				J. J. G. Geurts, L. Bo, P. J. W. Pouwels, J. A. Castelijns, C. H. Polman, and F. Barkhof Cortical Lesions in Multiple Sclerosis: Combined Postmortem MR Imaging and Histopathology AJNR Am. J. Neuroradiol., March 1, 2005; 26(3): 572 - 577. [Abstract] [Full Text] [PDF]

				P. A Narayana, J. S Wolinsky, S. B Rao, Renjie He, M. Mehta, and PROMiSe Trial MRSI Group Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis Multiple Sclerosis, June 1, 2004; 10(1_suppl): S73 - S78. [Abstract] [PDF]

				P. A Narayana, J. S Wolinsky, S. B Rao, R. He, M. Mehta, and PROMiSe Trial MRSI Group Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis Multiple Sclerosis, May 1, 2004; 10(3_suppl): S73 - S78. [Abstract] [PDF]

				S. Birnboim and A. Miller Cognitive strategies application of multiple sclerosis patients Multiple Sclerosis, February 1, 2004; 10(1): 67 - 73. [Abstract] [PDF]

				M Zarei, S Chandran, A Compston, and J Hodges Cognitive presentation of multiple sclerosis: evidence for a cortical variant J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 872 - 877. [Abstract] [Full Text] [PDF]

				D Pelletier, S J Nelson, J Oh, J P Antel, M Kita, S S Zamvil, and D E Goodkin MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 950 - 952. [Abstract] [Full Text] [PDF]

				M. Wylezinska, A. Cifelli, P. Jezzard, J. Palace, M. Alecci, and P. M. Matthews Thalamic neurodegeneration in relapsing-remitting multiple sclerosis Neurology, June 24, 2003; 60(12): 1949 - 1954. [Abstract] [Full Text] [PDF]

				N. De Stefano, P. M. Matthews, M. Filippi, F. Agosta, M. De Luca, M. L. Bartolozzi, L. Guidi, A. Ghezzi, E. Montanari, A. Cifelli, et al. Evidence of early cortical atrophy in MS: Relevance to white matter changes and disability Neurology, April 8, 2003; 60(7): 1157 - 1162. [Abstract] [Full Text] [PDF]

				I. Tsunoda, L.-Q. Kuang, J. E. Libbey, and R. S. Fujinami Axonal Injury Heralds Virus-Induced Demyelination Am. J. Pathol., April 1, 2003; 162(4): 1259 - 1269. [Abstract] [Full Text] [PDF]

				R. Srinivasan, R. Henry, D. Pelletier, and S. Nelson Standardized, Reproducible, High Resolution Global Measurements of T1 Relaxation Metrics in Cases of Multiple Sclerosis AJNR Am. J. Neuroradiol., January 1, 2003; 24(1): 58 - 67. [Abstract] [Full Text] [PDF]

				D. T. Chard, C. M. Griffin, M. A. McLean, P. Kapeller, R. Kapoor, A. J. Thompson, and D. H. Miller Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis Brain, October 1, 2002; 125(10): 2342 - 2352. [Abstract] [Full Text] [PDF]