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Clinical features of multiple sclerosis in a genetically homogeneous tropical population

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia

L G Palacio

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia, Department of Biology, University of Antioquia, School of Medicine, Medellin, Colombia

C S Uribe

Clinical Neurology Section, Medellin, Colombia

A C Londoño

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia

A Villa

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia

M Jiménez

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia

J M Anaya

Corporation for Biological Research, Medellin, Colombia

I Jiménez

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia

M Camargo

Department of Biology, University of Antioquia, School of Medicine, Medellin, Colombia

M Arcos-Burgos

Neurological Institute of Antioquia (NIA), University of Antioquia, Medellin, Colombia, Department of Biology, University of Antioquia, School of Medicine, Medellin, Colombia

Individuals affected with multiple sclerosis (MS) from a genetically homogeneous Caucasian population in Antioquia, a tropical region of Colombia, were evaluated in order to observe the clinical behavior of the disease. The frequency of clinical manifestations in 65 patients with definite MS from Antioquia was compared with those reported from temperate regions. The most common manifestations were optic neuritis and motor symptoms with absence of cerebellar symptoms. This presentation is significantly different from the frequency distribution at onset in series from temperate regions. These differences suggest that environmental factors could modify the clinical expression of MS in this population.

Key Words: multiple sclerosis • tropical neurology • MRI • myelopathy • optic neuritis • prevalence-Colombia

Multiple Sclerosis, Vol. 7, No. 4, 227-229 (2001)
DOI: 10.1177/135245850100700403


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