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Multiple sclerosis and oligodendroglioma

Department of Neurology, University of California, San Francisco, California, CA 94143-0114, USA

Andrew W Bollen

Department of Pathology, University of California, San Francisco, California, CA 94143-0506, USA

Mitchel S Berger

Department of Neurological Surgery, University of California, San Francisco, California, CA 94143-0112, USA

Jorge R Oksenberg

Department of Neurology, University of California, San Francisco, California, CA 94143-0114, USA

Stephen L Hauser

Department of Neurology, University of California, San Francisco, California, CA 94143-0114, USA

Two cases of multiple sclerosis (MS) and oligodendroglioma are reviewed, increasing the total number of reported cases to 11. In this series, the clinical onset of MS preceded the discovery of the tumor by a mean of 15 years. No distinguishing features of oligodendroglioma were characteristic of MS-associated cases. However, there was an overrepresentation of benign MS. Although this could result from biased ascertainment, other possibilities, including effective remyelination mediated by mitotically active oligodendrocytes, or secretion of immunosuppressive cytokines by the tumor tissue, cannot be excluded. It is likely that the coexistence of MS and oligodendroglioma is due to chance alone, nonetheless the possibility that glioma derived factors can moderate the disease course in MS is deserving of further study.

Key Words: multiple sclerosis • oligodendroglioma • glioma • oligodendrocyte

Multiple Sclerosis, Vol. 7, No. 4, 269-273 (2001)
DOI: 10.1177/135245850100700410


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