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Changes in motor cortex activation after recovery from spinal cord inflammation

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, MGH-NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA, The Clinical Investigator Training Program, Harvard-MIT Division of Health Sciences and Technology and Beth Israel-Deaconess Medical Center in collaboration with Pfizer Inc., Harvard Medical School, Boston, Massachusetts, USA, Department of Neurology, University of Washington, 1959 NE Pacific St., Box 356465, Seattle, WA 98195, USA

E Fray

MGH-NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

A Tievsky

MGH-NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA, Radiology Consultants of North Dallas, Medical City Dallas Hospital, Dallas, TX 12700 Park Central Drive Suite 430, Dallas, TX 75251, USA

R A Parker

Biometrics Center, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

P N Riskind

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, Department of Neurology, University of Massachusetts, Worcester, MA, USA

M C Stein

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

V Wedeen

MGH-NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

B R Rosen

MGH-NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Diseases of the spinal cord are associated with reactive changes in cerebral cortex organization. Many studies in this area have examined spinal cord conditions not associated with recovery, making it difficult to consider the value of these cortical events in the restoration of neurological function. We studied patients with myelitis, a syndrome of transient spinal cord inflammation, in order to probe cortical changes that might contribute to recovery after disease of the spinal cord. Seven patients, each of whom showed improvement in hand motor function after a diagnosis of myelitis involving cervical spinal cord, were clinically evaluated then studied with functional MRI. During right and left index finger tapping, activation volumes were assessed in three cortical motor regions within each hemisphere. Results were compared with findings in nine control subjects. Compared to the control group, myelitis patients had larger activation volumes within contralateral sensorimotor as well as contralateral premotor cortex. The degree of daily hand use showed a significant correlation with the volume of activation in contralateral sensorimotor cortex. Recovery from myelitis is associated with an enlarged activation volume in contralateral motor cortices. This change in motor cortex function is related to behavioral experience, and thus may contribute to motor improvement. The expanded activation in motor cortex, seen with several forms of spinal cord insult, may have maximal utility when corticospinal tract axons are preserved.

Key Words: recovery • inflammation • spinal cord • plasticity • sensorimotor cortex

Multiple Sclerosis, Vol. 7, No. 6, 364-370 (2001)
DOI: 10.1177/135245850100700604


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