This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Moore, G R. Articles by Nugent, R A Search for Related Content PubMed PubMed Citation Articles by Moore, G R. Articles by Nugent, R A Social Bookmarking                   What's this?

Baló's concentric sclerosis: surviving normal myelin in a patient with a relapsing-remitting clinical course

Department of Pathology and Laboratory Medicine (Neuropathology), Vancouver Hospital and Health Services Centre, Vancouver, BC, Canada, The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

K Berry

Department of Pathology and Laboratory Medicine (Neuropathology), St Paul's Hospital, Vancouver, BC, Canada, The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

J JF Oger

Department of Medicine (Neurology), Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada, The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

A JE Prout

Department of Medicine (Neurology), St Paul's Hospital, Vancouver, BC, Canada,The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

D A Graeb

Department of Radiology (Neuroradiology), Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada, The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

R A Nugent

Department of Radiology (Neuroradiology), Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada, The University of British Columbia, Vancouver, BC, Canada V5Z 1L8

Baló's concentric sclerosis is a demyelinating disorder in which bands of demyelination alternate with concentric bands of myelin preservation. The pathogenesis of the lesion is unknown. Previous reports using modern histopathologic techniques have shown the bands of myelin preservation to be comprised of remyelinated or partially demyelinated myelin. Here we report a case of Baló's concentric sclerosis in a 24-year-old East Indian patient with a previous history of relapsing-remitting multiple sclerosis (MS). Pathologically, the bands of myelin preservation showed myelin sheaths of normal thickness, with focal areas of demyelination. The findings, taken together with those of previously reported cases, suggest that Baló's concentric sclerosis is a variant of MS, and the concentric lesion may be an intermediary form in evolution of a chronic active MS plaque. The pathogenesis of this concentric lesion may be explained by periodic suppression of demyelination in the rapidly expanding border, allowing remyelination or only transient incomplete demyelination to occur.

Key Words: multiple sclerosis • Balo's concentric sclerosis • myelin • demyelination • magnetic resonance imaging

Multiple Sclerosis, Vol. 7, No. 6, 375-382 (2001)
DOI: 10.1177/135245850100700606


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. Pohl, E. Waubant, B. Banwell, D. Chabas, T. Chitnis, B. Weinstock-Guttman, S. Tenembaum, and for the International Pediatric MS Study Group Treatment of pediatric multiple sclerosis and variants Neurology, April 17, 2007; 68(16_suppl_2): S54 - S65. [Abstract] [Full Text] [PDF]

				D Pohl, K Rostasy, B Krone, and F Hanefeld Balo's concentric sclerosis associated with primary human herpesvirus 6 infection J. Neurol. Neurosurg. Psychiatry, December 1, 2005; 76(12): 1723 - 1725. [Abstract] [Full Text] [PDF]

				S. Love Establishing preconditions for Balo's concentric sclerosis Brain, May 1, 2005; 128(5): 960 - 962. [Full Text] [PDF]