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International consensus statement on the use of disease-modifying agents in multiple sclerosis

Multiple Sclerosis Research Clinic, The Ottawa Hospital - General Campus, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6, mfreedman{at}ottawahospital.on.ca

L D Blumhardt

Division of Clinical Neurology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK

B Brochet

Service de Neurologie, Hôpital Pellegrin, Fédération des Neurosciences Cliniques du CHU de Bordeaux, Bordeaux Cedex 33076, France

G Comi

Department of Neurophysiology, University of Milan, IRCCS Ospedale San Raffaele, via Olgettina 60, Milan 20132, Italy

J H Noseworthy

Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA

M Sandberg-Wollheim

Department of Neurology, Lund University Hospital, Lund S-22185, Sweden

P Soelberg Sørensen

Neuroscience Centre, Copenhagen University Hospital, Copenhagen D-2100, Denmark

Paris Workshop Group

Objective: To provide recommendations on the use of disease-modifying agents in the management of multiple sclerosis (MS) and to ensure that treatment will be available to those patients who may benefit. Methods: An initial draft of the consensus statement was prepared by the Steering Committee and amended in the light of written comments from a group of MS specialists. At a subsequent workshop, the wording of the consensus statement was discussed, modified if necessary, and the participants indicated their level of support using an electronic voting system. A new draft of the statement was then sent to a much larger group of international opinion leaders in MS for further comment. Results: A number of statements were agreed, which outline the criteria for consideration of disease-modifying therapy for MS and recommendations for treatment. Each statement was accepted completely, or with only minor reservations by 95% or more of those present at the workshop. Conclusions: Periodic reviews and modifications to the statement will be required, as new approaches to the treatment of MS and other therapeutic agents become available.

Key Words: consensus • glatiramer acetate • interferon beta • multiple sclerosis

Multiple Sclerosis, Vol. 8, No. 1, 19-23 (2002)
DOI: 10.1191/1352458502ms769oa


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