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High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up study

Neurology Services of the University Hospital La Fe, Valencia, Spain, bcasanovae{at}meditex.es

F Coret

The Clinic University Hospital, Valencia, Spain

C Valero

Neurology Services of the University Hospital La Fe, Valencia, Spain

L Landete

The University Hospital, Dr. Peset, Valencia, Spain

A Pascual

The Clinic University Hospital, Valencia, Spain

J J Vilchez

Neurology Services of the University Hospital La Fe, Valencia, Spain

Objective: To study if there are different patterns of clinical activity - measured by the annual exacerbation rate (AER) - among relapsing-remitting multiple sclerosis (RRMS), "early" secondary multiple sclerosis (SPMS) and "late" SPMS. Methods: A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR). Results: A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found. Conclusions: The SPMS has a high clinical inflammatory activity before and during its transformation from a RRMS.

Key Words: multiple sclerosis • natural history of multiple sclerosis • secondary progressive multiple sclerosis

Multiple Sclerosis, Vol. 8, No. 1, 59-63 (2002)
DOI: 10.1191/1352458502ms773oa


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