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Multiple Sclerosis
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High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up study

B. Casanova

Neurology Services of the University Hospital La Fe, Valencia, Spain

F. Coret

The Clinic University Hospital, Valencia, Spain

C. Valero

Neurology Services of the University Hospital La Fe, Valencia, Spain

L. Landete

The University Hospital, Dr. Peset, Valencia, Spain

A. Pascual

The Clinic University Hospital, Valencia, Spain

JJ Vilchez

Neurology Services of the University Hospital La Fe, Valencia, Spain

Objective: To study if there are different patterns of clinical activity - measured by the annual exacerbation rate (AER) - among relapsing-remitting multiple sclerosis (RRMS), "early" secondary multiple sclerosis (SPMS) and "late" SPMS. Methods: A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR). Results: A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found. Conclusions: The SPMS has a high clinical inflammatory activity before and during its transformation from a RRMS. Multiple Sclerosis (2002) 8, 59-63

Key Words: Key words: multiple sclerosis • natural history of multiple sclerosis • secondary progressive multiple sclerosis

Multiple Sclerosis, Vol. 8, No. 1 suppl, 59-63 (2002)
DOI: 10.1177/135245850200800111
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