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Cerebral plasticity in multiple sclerosis: insights from fMRI

Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK

P M Matthews

Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK, paul{at}fmrib.ox.ac.uk

Functional magnetic resonance imaging (fMRI) allows noninvasive localization of cerebral activation with relatively high spatial and temporal resolution. The considerable potential for the elucidation of the mechanisms of brain function has made it a useful tool to investigate the neural substrate of motor, sensory and cognitive functions. Understanding derived from these basic cognitive neuroscience investigations is beginning to be applied to clinically relevant problems. In this article, applications to multiple sclerosis (MS) are reviewed, which address the challenging notion that adaptive cerebral plasticity may have an important influence on the relationship between MS pathology and its clinical expression.

Key Words: brain • disability • fMRI • multiple sclerosis • recovery

Multiple Sclerosis, Vol. 8, No. 3, 193-199 (2002)
DOI: 10.1191/1352458502ms820oa


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