This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Uzuner, N Articles by Özdemir, G Search for Related Content PubMed PubMed Citation Articles by Uzuner, N Articles by Özdemir, G Pubmed/NCBI databases Medline Plus Health Information Multiple Sclerosis Social Bookmarking                         What's this?

Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis

Department of Neurology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey, nuzuner{at}ogu.edu.tr

S Özkan

Department of Neurology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey

D Gücüyener

Department of Neurology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey

G Özdemir

Department of Neurology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey

We assessed the blood flow velocity (BFv) changes to visual stimuli using transcranial Doppler (TCD) in patients with multiple sclerosis (MS) during an exacerbation period by means of vasoneuronal coupling. Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both posterior cerebral arteries (PCAs) were simultaneously monitored by TCD sonography during 10 cycles of 20 s eyes open observing complex moving visual images, and 20 s eyes closed at the end of every cycle. TCD sonography was performed at least at the first 2 days of exacerbation. Mean cerebral BFv throughout the procedure (p =0.003, p =0.001; right and left sides, respectively), velocity at rest (p =0.001, p <0.001), and velocity at stimulation (p =0.021, p =0.01) on both PCAs were significantly lower in patients than controls. However, BFv changes to visual stimulation on both sides were significantly higher in patients (p =0.01, p =0.031) compared to controls. There were negative correlations between P100 latencies and relative blood flow changes on both sides, but it was not significant on the left side. These results may suggest that patients with MS during exacerbation have more reactive vessels in the posterior circulation and/or more reactive neurons in the occipital cortex.

Key Words: functional ultrasonography • multiple sclerosis • transcranial Doppler • vasomotor reactivity • vasoneuronal coupling

Multiple Sclerosis, Vol. 8, No. 3, 217-221 (2002)
DOI: 10.1191/1352458502ms798oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Nakagawa, J. M. Serrador, S. L. LaRose, F. Moslehi, L. A. Lipsitz, and F. A. Sorond Autoregulation in the Posterior Circulation Is Altered by the Metabolic State of the Visual Cortex Stroke, June 1, 2009; 40(6): 2062 - 2067. [Abstract] [Full Text] [PDF]

				N. Uzuner, S. Ozkan, and N. Cinar Cerebrovascular reactivity in multiple sclerosis patients Multiple Sclerosis, July 1, 2007; 13(6): 737 - 741. [Abstract] [PDF]