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Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? Conflicting results

Carolinas Medical Center, ROB #410, PO Box 32861, Charlotte, North Carolina 28232-2861, USA, Michael.Kaufman{at}carolinashealthcare.org

C A Gaydos

Johns Hopkins University, Division of Infectious Diseases, 1159 Ross Bldg., 720 Rutland Ave., Baltimore, Maryland 21205, USA

S Sriram

Department of Neurology, Vanderbilt University Medical Center, Vanderbilt Stallworth Rehab, 2201 Capers Ave., Room 1222, Nashville, Tennessee 37212-3164, USA

J Boman

Department of Virology, University of Umeâ, SE-901 85 Umeâ, Sweden

M L Tondella

Center for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, Georgia 30333, USA

H J Norton

Carolinas Medical Center, ROB #410, PO Box 32861, Charlotte, North Carolina 28232-2861, USA

Cerebrospinal fluid samples from controls and patients with multiple sclerosis (MS) were split and sent to laboratories with different experiences for the detection of Chlamydia pneumoniae by polymerase chain reaction. Vanderbilt investigators identified C. pneumoniae in the majority of patients with MS and uncommonly in controls. Laboratories at Johns Hopkins University, University of Umea3, and the Centers for Disease Control and Prevention did not identify C. pneumoniae in any of the samples. Conflicting reports of C. pneumoniae detection in the same samples from patients with MS highlight the need to exchange detection techniques among laboratories involved in this controversy.

Key Words: Chlamydia pneumoniae • multiple sclerosis • polymerase chain reaction

Multiple Sclerosis, Vol. 8, No. 4, 289-294 (2002)
DOI: 10.1191/1352458502ms815oa


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