This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hickman, S J Articles by Miller, D H Search for Related Content PubMed PubMed Citation Articles by Hickman, S J Articles by Miller, D H Social Bookmarking                         What's this?

Technical note: the comparison of hypointense lesions from ‘pseudo-T1’ and T1-weighted images in secondary progressive multiple sclerosis

NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

G J Barker

NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

P D Molyneux

NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK

D H Miller

NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK, d.miller{at}ion.ucl.ac.uk

There is a large historical database of dual-echo conventional spin-echo (CSE) magnetic resonance images in multiple sclerosis (MS). If new analysis techniques can be developed then this database could provide valuable information. We have investigated a technique in which the late echo of a dual-echo data set is subtracted from the corresponding early echoyielding images, which appear qualitatively similar to T1- weighted images. This study investigated whether the hypointense lesions on the ‘pseudo-T1’ images (created as described above) were related to hypointense lesions on conventional T1-weighted images. The hypointense lesion areas were measured by a blinded observer using a computer-assisted contouring technique applied to pseudo-T1 and T1-weighted CSE images obtained from 17 patients with secondary progressive MS (SPMS). The mean hypointense lesion area from T1-weighted images was 2218- 2072 mm², compared to 1426-1353 mm² from pseudo-T1 images (p =0.008). There was, however, a strong correlation between the values obtained from the two sets of images (r =0.93, p <0.001). The strong correlation between the values obtained from the two sets of images suggests that pseudo-T1 images may be useful to investigate a subgroup of more destructive lesions in MS from historical databases and in future prospective studies when imaging time is limited.

Key Words: adult • axons/pathology • chronic progressive/pathology • human • magnetic resonance imaging • multiple sclerosis

Multiple Sclerosis, Vol. 8, No. 5, 433-435 (2002)
DOI: 10.1191/1352458502ms824xx


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?