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TACE mRNA expression in peripheral mononuclear cells precedes new lesions on MRI in multiple sclerosis

Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria, thomas.seifert{at}kfunigraz.ac.at

B C Kieseier

Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria

S Ropele

MRI Center, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria

S Strasser-Fuchs

Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria

F Quehenberger

Institute for Medical Informatics, Statistics and Documentation, Karl Franzens University, Engelgasse 13, Graz A-8010, Austria

F Fazekas

Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria, MRI Center, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria

H-P Hartung

Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, Graz A-8036, Austria

Tumor necrosis factor-a (TNF-a) is involved in the pathogenesis of multiple sclerosis (MS). It has to be released from its cell membrane-bound precursor by proteolytic cleavage. This is mainly performed by a member of the ADAM (a disintegrin and metalloproteinase) family of enzymes, TNF-a-converting enzyme (TACE, ADAM 17). In a longitudinal study on 11 relapsing-remitting MS patients, we qualitatively determined mRNA expression of TNF-a and TACE in peripheral blood mononuclear cells (PBMCs) without ex vivo stimulation. mRNA expression was related to disease activity as assessed by monthly gadolinium (Gd)-enhanced brain magnetic resonance imaging (MRI). Patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new Gd-enhancing lesions per scan one month following PBMC sampling.

Key Words: multiple sclerosis • TACE • TNF-

Multiple Sclerosis, Vol. 8, No. 6, 447-451 (2002)
DOI: 10.1191/1352458502ms830oa


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