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Multiple Sclerosis, Vol. 8, No. 6, 534-536 (2002)
DOI: 10.1191/1352458502ms852xx

Arthritis during interferon beta-1b treatment in multiple sclerosis

A Altintas

Department of Neurology, Cerrahpasa School of Medicine, 34300 Istanbul, Turkey, aaltintas.md{at}superonline.com

Y Alici

Department of Neurology, Cerrahpasa School of Medicine, 34300 Istanbul, Turkey

M Melikoglu

Department of Rheumatology, Cerrahpasa School of Medicine, 34300 Istanbul, Turkey

A Siva

Department of Neurology, Cerrahpasa School of Medicine, 34300 Istanbul, Turkey

Interferon beta (IFN-ß) is the most widely prescribed disease-modifying drug for multiple sclerosis (MS). Therapy with IFN-ßmay be associated with a number of adverse reactions. The development or exacerbation of other autoimmune diseases is a rare but reported side effect of IFN-ßtherapy. In this case report, we present clinical and laboratory findings of two MS patients who developed arthritis during IFN-ß1b treatment, probably of autoimmune origin.

Key Words: arthritis • interferons • multiple sclerosis


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