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Multiple Sclerosis, Vol. 9, No. 6, 550-553 (2003)
DOI: 10.1191/1352458503ms964oa

Co-occurrence of multiple sclerosis and myasthenia gravis in British C olumbia

C M Isbister

Department of Ophthalmology, Vancouver Hospital and Health Sciences Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC Canada

P J Mackenzie

Department of Ophthalmology, Vancouver Hospital and Health Sciences Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC Canada

D Anderson

Department of Ophthalmology, Vancouver Hospital and Health Sciences Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC Canada

N K Wade

Department of Ophthalmology, Vancouver Hospital and Health Sciences Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC Canada

J Oger

Department of Neurology, Vancouver Hospital and Health Sciences Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC Canada, joel.oger{at}ubc.ca

We describe eight patients with associated multiple sclerosis (MS) and myasthenia gravis (MG). Patients were less than 50 years old at the time of onset, and seven were female. The clinical course of both MS and MG was mild in most patients. To our knowledge, this represents the largest reported series. We provide further evidence for a nonrandom association of these two diseases and discuss common mechanisms of patho genesis.

Key Words: autoimmune diseases • epidemiology • multiple sclerosis • myasthenia gravis • nervous system


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