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Multiple Sclerosis
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Cytapheresis with a filter for selective removal of CD4+ T cells in experimental autoimmune encephalomyelitis

Shunya Nakane

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Hidenori Matsuo

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan, Division of Clinical Research Department of Surgery, Kawatana National Hospital, Nagasaki, Japan, hidenori{at}kawatana.hosp.go.jp

Hirofumi Goto

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan, Division of Clinical Research Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Megumi Yoshinaga-Matsumoto

Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Izumi Ohtsuru

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Katsuhiro Ichinose

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Hirokazu Onodera

Research and Development Laboratory, Asahi Medical Co., Ltd., Oita, Japan

Makoto Yoshida

Research and Development Laboratory, Asahi Medical Co., Ltd., Oita, Japan

Noritoshi Shibuya

Department of Neurology Department of Surgery, Kawatana National Hospital, Nagasaki, Japan

Experimental autoimmune encephalomyelitis (EAE) is a major animal model of human multiple sclerosis (MS). CD4+ T cells are thought to play a pivotal role in the patho genesis of EAE and MS. In order to investigate the depletio n of CD4+ T cells from the systemic circulation as an effective strategy for the treatment of MS, we performed extracorporeal CD4+ T cell adsorption, using a filter to which anti-CD4+ antibody is immobilized as a ligand, in adoptively transferred EAE. Rats treated with CD4+ T cell removal filter (C D4RF) exhibited milder clinical signs of EAE and earlier recovery than those receiving sham treatment. Moreover, the thymic cells from EAE rats treated with C D4RF exhibited a suppressed proliferative response and IFN-g production to myelin basic protein. These results suggest that depletion of CD4+ T cells from the systemic circulation by extracorporeal treatment is a potentially useful strategy for treatment of acute phase and relapsing MS.

Key Words: autoimmunity • C D4 • cytapheresis • experimental autoimmune encephalomyelitis (EA E) • immunotherapy • T cells

Multiple Sclerosis, Vol. 9, No. 6, 579-584 (2003)
DOI: 10.1191/1352458503ms968oa
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