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Multiple Sclerosis
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Fatigue in multiple sclerosis: relation to depression, physical impairment, personality and action control

I.-K. Penner

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland, ik.penner{at}unibas.ch

N. Bechtel

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland

C. Raselli

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland

M. Stöcklin

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland

K. Opwis

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland

L. Kappos

Department of Neurology, University Hospital Basel, Switzerland

P. Calabrese

Department of Cognitive Psychology and Methodology, University of Basel, Switzerland, Department of Neuropsychology and Behavioral Neurology, University Hospital Bochum, Germany

Athough fatigue is one of the most common symptoms of multiple sclerosis, it is yet poorly understood and therefore difficult to manage. To clarify the nature of fatigue we investigated its relationship to depression, physical impairment, personality and action control and compared these variables between a sample of 41 MS patients and 41 healthy controls. Physical impairment was assessed by the EDSS and all other dimensions, using questionnaires. Stepwise linear regression analyses revealed that physical impairment was related to physical fatigue in MS patients. Depression was the main factor influencing fatigue among both, MS patients and controls. What clearly differentiated the two groups was the correlation between fatigue and action control. Decreased levels of action control imply attentional and motivational deficits and were only found in fatigued MS patients. Our study indicates that motivational disturbances might be specific for MS related fatigue. Multiple Sclerosis 2007; 13: 1161—1167. http://msj.sagepub.com

Key Words: action control • depression • fatigue • motivation • personality traits • physical impairment

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Multiple Sclerosis, Vol. 13, No. 9, 1161-1167 (2007)
DOI: 10.1177/1352458507079267
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