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Multiple Sclerosis
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1352458506069926v1
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Article

Subtle upper limb impairment in asymptomatic multiple sclerosis subjects

Claudio Solaro1*, Giampaolo Brichetto2, Maura Casadio3, Luca Roccatagliata2, L Ruggiu3, Giovanni Luigi Mancardi2, Pietro Giovanni Morasso3, Paolo Tanganelli1, Vittorio Sanguineti3

1 Department of Neurology, Hospital 'P Antero Micone', Genova, Italy
2 Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
3 Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy

* To whom correspondence should be addressed.


  Abstract

We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control.

Key Words: asymptomatic, digitizing tablet, multiple sclerosis, upper limb, sensorimotor control

First published on February 9, 2007, doi:10.1177/1352458506069926

Multiple Sclerosis 2007;13:428.

A more recent version of this article appeared on April 1, 2007

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This article has been cited by other articles:


Home page
 Mult SclerHome page
M. Casadio, V. Sanguineti, P. Morasso, and C. Solaro
Abnormal sensorimotor control, but intact force field adaptation, in multiple sclerosis subjects with no clinical disability
Multiple Sclerosis, April 1, 2008; 14(3): 330 - 342.
[Abstract] [PDF]

Home page
 The International Journal of Robotics ResearchHome page
M. Casadio, V. Sanguineti, C. Solaro, and P. G. Morasso
A Haptic Robot Reveals the Adaptation Capability of Individuals with Multiple Sclerosis
The International Journal of Robotics Research, November 1, 2007; 26(11-12): 1225 - 1233.
[Abstract] [PDF]


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