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Multiple Sclerosis
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*Multiple Sclerosis
*Urine and Urination
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Article

Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis

Diego Centonze1*, F Petta2, V Versace1, S Rossi1, F Torelli1, C Prosperetti1, St Rossi1, G A Marfia1, G Bernardi1, G Koch1, R Miano2, L Boffa1, E Finazzi-Agrò2

1 Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy
2 Clinica Urologica, Università Tor Vergata, Rome, Italy

* To whom correspondence should be addressed.


  Abstract

We tested the effects of 5-Hz rTMS over the motor cortex in multiple sclerosis (MS) subjects complaining of lower urinary tract symptoms either in the filling or voiding phase. Our data show that motor cortex stimulation for five consecutive days over two weeks ameliorates the voiding phase of the micturition cycle, suggesting that enhancing corticospinal tract excitability might be useful to ameliorate detrusor contraction and/or urethral sphincter relaxation in MS patients with bladder dysfunction.

Key Words: cortex, detrusor overactivity, motor cortex, rTMS, voiding dysfunction

First published on January 29, 2007, doi:10.1177/1352458506070729

Multiple Sclerosis 2007;13:269.

A more recent version of this article appeared on March 1, 2007

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