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Multiple Sclerosis
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1352458506070732v1
13/2/256    most recent
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Article

Immunosuppressive therapy is more effective than interferon in neuromyelitis optica

C Papeix1*, J-S Vidal2, J de Seze3, C Pierrot-Deseilligny1, A Tourbah1, B Stankoff4, C Leburn5, T Moreau6, P Vermersch3, B Fontaine1, O Lyon-Caen1, O Gout7

1 Department of Neurology, Hôpital de la Salpêtrière, Paris, France
2 Institut National de la Santé et de la Recherche Médicale Unité 708, Hôpital de la Salpêtrière, Paris, France
3 Department of Neurology, CHU de Lille, Lille, France
4 Centre d'Investigation Clinique, Hôpital de la Salpêtrière, Paris, France
5 Department of Neurology, CHU de Nice, Nice, France
6 Department of Neurology, CHU de Dijon, Dijon, France
7 Department of Neurology, Fondation Ophtalmologique A. de Rothschild, Paris, France

* To whom correspondence should be addressed.


  Abstract

To determine long-term treatment (LTT) of neuromyelitis optica (NMO), we retrospectively reviewed therapies of 26 patients with NMO followed in five French neurological departments. To assess LTT efficacy, the probability of relapse free after LTT was analysed. Patients were divided into two groups according to the first treatment receiving interferon beta (IFN Group, seven patients) or immunosuppressants (IS Group, 19 patients). The probability of relapse was significantly lower in the IS Group (P=0.0007). From our results, interferon beta is not recommended, and one of the best current therapeutic options for NMO appears to be immunosuppressants.

Key Words: beta interferon, immunosuppressive therapy, neuromyelitis optica

First published on January 29, 2007, doi:10.1177/1352458506070732

Multiple Sclerosis 2007;13:256.

A more recent version of this article appeared on March 1, 2007

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