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Multiple Sclerosis
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Article

Autoimmune hemolytic anemia during interferon-beta-1b treatment for multiple sclerosis

Guchan Alanoglu1*, Serkan Kilbas2, Cagatay Arslan3, Altug Senol3, Suleyman Kutluhan2

1 Department of Internal Medicine, Division of Hematology, School of Medicine, Suleyman Demirel University, 32100 Isparta, Turkey
2 Department of Neurology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
3 Department of Internal Medicine, School of Medicine, Suleyman Demirel University, Isparta, Turkey

* To whom correspondence should be addressed.


  Abstract

A 31-year-old patient with multiple sclerosis (MS), treated with interferon beta-1b (IFNB-1b) for two years, presented with fatigue and dizziness. Coombs' positive autoimmune hemolytic anemia (AIHA) was found. Other potential etiologies of AIHA were ruled out. An association with IFNB-1b was highly suspected. Interferon therapy was discontinued and prednisone therapy instituted. There was resolution of the hemolytic anemia, and prednisone therapy was tapered gradually. To the best of our knowledge, there is no reported case of the development of AIHA associated with IFNB-1b use in MS patients. We conclude that if an unexplained drop in hematocrit occurs with a MS patient receiving IFNB-1b, autoimmune mediated hemolysis should also be considered.

Key Words: autoimmune hemolytic anemia, interferon beta-1b treatment, multiple sclerosis

First published on March 15, 2007, doi:10.1177/1352458506071333

Multiple Sclerosis 2007;13:683.

A more recent version of this article appeared on June 1, 2007

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