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Primary progressive multiple sclerosis: a comparative study of the diagnostic criteria
1 Department of Neurology, Hôpital Civil, Strasbourg, France
* To whom correspondence should be addressed.
We assessed the different sets of diagnostic criteria for primary progressive multiple sclerosis (PPMS), in order to determine their sensitivity when applied to a cohort of 261 PPMS patients. According to the Thompson criteria, 168 patients (64.4%) had definite PPMS, 84 patients (32.2%) had probable PPMS, and nine patients (3.4%) had possible PPMS; according to the McDonald criteria, 180 patients (69%) had PPMS; according to the revised McDonald criteria, 194 patients (74.3%) had PPMS. Our findings indicate that the revised McDonald criteria are more sensitive than the original McDonald criteria, but less sensitive than the Thompson criteria. Key Words: multiple sclerosis, criteria, MRI, pensidiagnosis
First published on February 16, 2007, doi:10.1177/1352458506071767 |
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