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Multiple Sclerosis
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Article

A follow-up study of Nordic multiple sclerosis candidate gene regions

Hanne F. Harbo1*, Pameli Datta2, Lars P Ryder3, Eva Akesson4, John Benedikz5, Elisabeth G. Celius6, O Anderson7, Kjell-Morten Myhr8, Magnhild Sandberg-Wollheim9, Jan Hillert4, Arne Svejgaard3, Per Soelberg Sorensen1, Anne Spurkland10, Annette Oturai1

1 Danish Multiple Sclerosis Research Centre, Copenhagen, Denmark
2 Institute of Immunology, Faculty Division Rikshospitalet University of Oslo, Oslo, Norway
3 Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark
4 Department of Neurology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
5 Multiple Sclerosis Rehabilitation and Diagnostic Center of the MS Society of Iceland, Reykjavik, Iceland
6 Department of Neurology, Ullevål University Hospital, Oslo, Norway
7 Department of Neurology, Gothenburg University Hospital, Gothenburg, Sweden
8 Department of Neurology, Haukeland University Hospital and Department of Clinical Medicine, Section for Neurology, University of Bergen, Bergen, Norway
9 Department of Neurology, Lund University Hospital, Lund, Sweden
10 Department of Anatomy, Institute of Basal Medical Sciences, University of Oslo, Oslo, Norway

* To whom correspondence should be addressed.


  Abstract

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected=0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.

Key Words: candidate regions, GAMES, genetics, HLA, LD screens, multiple sclerosis, Nordic countries

First published on February 9, 2007, doi:10.1177/1352458506071790

Multiple Sclerosis 2007;13:584.

A more recent version of this article appeared on June 1, 2007

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