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Multiple Sclerosis
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Article

Conjugal multiple sclerosis in Isfahan, Iran: a population-based study

A.H. Maghzi1*, M. Etemadifar2, V. Shaygannejad2, M. Saadatnia2, M. Salehi3, A. Hassanzadeh4

1 Medical School, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran
2 Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, 81744, Iran
3 Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran
4 Department of Epidemiology and Biostatistics, Medical School, Isfahan University of Medical Sciences, Isfahan, 814450-4500, Iran

* To whom correspondence should be addressed.


  Abstract

Conjugal multiple sclerosis (MS) is a rare form of MS in which both spouses are affected, and at least one is affected after marriage. Among 1606 definite MS patients, 1076 were in marital relationship, among whom we identified six conjugal pairs, giving the conjugal rate of 0.5%. This rate is 12.5 times higher than the estimated risk of MS for the general population (0.04%). The observed conjugal rate suggests an increased risk of developing MS for MS patients' spouses, this could be due to transmission or, more likely, to the same environmental factors shared in adult life.

Key Words: conjugal multiple sclerosis, environmental factors, epidemiology, aetiology, marriage, Iran, Isfahan

First published on February 9, 2007, doi:10.1177/1352458506072092

Multiple Sclerosis 2007;13:673.

A more recent version of this article appeared on June 1, 2007

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