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Multiple Sclerosis
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1352458506073502v1
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Article

Autologous hematopoietic stem cell transplantation for very active relapsing-remitting multiple sclerosis: report of two cases

Emilio Portaccio1*, Maria Pia Amato1, G Siracusa1, F Pagliai2, S Sorbi1, Stefano Guidi2, A Bosi2, R Saccardi2

1 Department of Neurology, University of Florence, Florence, Italy
2 Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy

* To whom correspondence should be addressed.


  Abstract

Autologous hematopoietic stem cell transplantation (AHSCT) has been proposed as a rescue treatment in multiple sclerosis (MS) patients not responding to first- or second-line therapies. To date, most of the treated cases had a secondary progressive disease course. However, patients with high inflammatory activity, but no secondary progression of the disease, could be candidates to take greater advantage of AHSCT. In this paper, we report two cases with very active, relapsing-remitting (RR) MS, who underwent AHSCT, and obtained a dramatic resolution to disease activity.

Key Words: autologous stem cell transplantation, multiple sclerosis

First published on February 16, 2007, doi:10.1177/1352458506073502

Multiple Sclerosis 2007;13:676.

A more recent version of this article appeared on June 1, 2007

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This article has been cited by other articles:


Home page
 Mult SclerHome page
J Fagius, J Lundgren, and G Oberg
Early highly aggressive MS successfully treated by hematopoietic stem cell transplantation
Multiple Sclerosis, February 1, 2009; 15(2): 229 - 237.
[Abstract] [PDF]


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