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Multiple Sclerosis
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1352458507076411v1
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Article

Deep grey matter 'black T2' on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

Y Zhang1, Rk Zabad2, X Wei1, L M Metz2, M D Hill2, J R Mitchell1*

1 Department of Radiology, University of Calgary, Calgary T2N 2T9, Canada
2 Hotchkiss Brain Institute, University of Calgary, Calgary T2N 2T9, Canada

* To whom correspondence should be addressed.


  Abstract

T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5 T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3 T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r= - 0.5, P<0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study. Mulitple Sclerosis 2007; 00; 000-000. http://msj.sagepub.com

Key Words: black T2; high field MRI; multiple sclerosis; disability; deep grey matter; iron deposition

First published on April 27, 2007, doi:10.1177/1352458507076411

Multiple Sclerosis 2007;13:880.

A more recent version of this article appeared on August 1, 2007

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