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Multiple Sclerosis
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Article

The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study

Luca Roccatagliata1, M A Rocca2, P Valsasina2, L Bonzano1, M P Sormani3, R Saccardi4, G L Mancardi1, M Filippi2*

1 Department of Neuroscience, Ophtalmology and Genetics, University of Genoa, Genoa
2 Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan
3 Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University San Raffaele, Milan and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa
4 Bone Marrow Transplantation Unit, University of Florence, Florence, Italy

* To whom correspondence should be addressed.


  Abstract

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment. Multiple Sclerosis 2007; 00: 000-000. http://msj.sagepub.com

Key Words: atrophy; autologous hematopoietic stem cell transplantation; magnetic resonance imaging; multiple sclerosis

First published on April 27, 2007, doi:10.1177/1352458507076982

Multiple Sclerosis 2007;13:1068.

A more recent version of this article appeared on September 1, 2007

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