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First published on October 17, 2007, doi:10.1177/1352458507080733

Multiple Sclerosis 2008;14:219.

A more recent version of this article appeared on March 1, 2008

Article

Validation of the Multiple Sclerosis International Quality of Life questionnaire

M C Simeoni1, P Auquier1*, O Fernandez2, Peter Flachenecker3, S Stecchi4, C S Constantinescu5, E Idiman6, A Boyko7, A.G Beiske8, Timothy Vollmer9, A Triantafillou10, P O'Connor11, Y Barak12, L Biermann13, E Cristiano14, Samir F Atweh15, Dl Patrick16, S Robitail1, N Ammoury17, A Beresniak18, and J Pelletier19

1 Department of Public Health, Timone University Hospital, Marseille, France
2 Hospital Regional Universitario Carlos Haya, Málaga, Spain
3 Department of Neurology, University of Würzburg, Würzburg, Germany
4 Centro SM, Villa Mazzacorati, Bologna, Italy
5 Division of Clinical Neurology, University Hospital, University of Nottingham, Nottingham, UK
6 Dokuz Eylül Üniversity, Department of Neurology, Izmir, Turkey
7 Department of Neurology, Russian State Medical University, Moscow, Russia
8 Department of Neurology, Akershus University Hospital, Lørenskog, Norway
9 Van Denburgh Chair, Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA
10 Department of Neurology, Aristotle University of Thessaloniki, AHEPA Hospital, Greece
11 St Michael's Hospital, University of Toronto, Ontario, Canada
12 SHEBA MC, Tel-HaShomer and the Sackler School of Medicine, Tel Aviv, Israel
13 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
14 Department of Neurology, University of Buenos Aires, Head Neurology Hospital Italiano de Buenos Aires, Argentina
15 Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon
16 Department of Neurology, University of Washington, Seattle, USA
17 Serono International S.A., Geneva, Switzerland
18 Laboratory of Applied Health Economics LIRAES, University Paris 5, France
19 Department of Neurology, Timone University Hospital, Marseille, France

* To whom correspondence should be addressed.


  Abstract

This study aims to validate the Multiple Sclerosis (MS) International Quality of Life (MusiQoL) questionnaire, a multi-dimensional, self-administered questionnaire, available in 14 languages, as a disease-specific quality of life scale that can be applied internationally. A total of 1992 patients with different types and severities of MS from 15 countries were recruited. At baseline and day 21 ± 7, each patient completed the MusiQoL, a symptom checklist and the short-form (SF)-36 QoL questionnaire. Neurologists also collected socio-demographic, MS history and outcome data. The database were randomly divided into two subgroups and analysed according to different patient characteristics. For each model, psychometric properties were tested and the number of items was reduced by various statistical methods. Construct validity, internal consistency, reproducibility and external consistency were also tested. Nine dimensions, explaining 71% of the total variance, were isolated. Internal consistency and reproducibility were satisfactory for all the dimensions. External validity testing revealed that dimension scores correlated significantly with all SF-36 scores, but showed discriminant validity by gender, socio-economic and health status. Significant correlations were found between activity in daily life scores and clinical indices. These results demonstrate the validity and reliability of the MusiQoL as an international scale to evaluate QoL in patients with MS.

Key Words: international; multiple sclerosis; MusiQoL; quality of life; questionnaire; validation


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